2.9. DILIsym Models

2.9. DILIsym Models

DILIsym is a quantitative systems toxicology software package that predicts drug-induced liver injury (DILI). It requires time intensive and expensive in vitro assay results as inputs into the program. It is desirable to enable the use of DILIsym at earlier stages of drug development through machine learning (ML) inputs to the platform. Thus, in house and published data were collected to create ML models. These models comprise the DILIsym Inputs module. There are eleven models in the module that predict mitochondrial dysfunction, reactive oxygen species (ROS) toxicity, and inhibition of MRP3 (multidrug resistance-associated protein 3), BSEP (bile salt export pump), and MDR3 (multidrug resistance protein 3) transporters. The BSEP models ([BSEP_Inh] and [BSEP_IC50]) are described in the Transporter Models section of this manual and the remaining models are described below.